A family-based substance abuse prevention program was evaluated which emphasizes family cohesion, school and peer attachment, self-esteem, and attitudes about adolescent use of alcohol and tobacco. The program was implemented in rural communities and targeted families with students entering middle or junior high school. Baseline surveys were conducted with students and parents in four schools and were re-administered one year later. Because the program was voluntary, a quasi-experimental design was used to compare participants (29 students and 28 parents) and non participants (268 students and 134 parents). At the one-year follow-up, analyses of covariance indicated that student participants, as compared to non-participants, had higher family cohesion, less family fighting, greater school attachment, higher self-esteem, and believed that alcohol should be consumed at an older age. There were fewer significant results for parent participants at the one-year follow-up. Strategies for involving parents in prevention programs are discussed.